No copies of the NME associated markers (homozygous for normal). Talarico LR, Schatzberg SJ. Clinically, Pug Dog Encephalitis (PDE) is described as a Necrotizing Meningoencephalitis (NME) – and the terms PDE and NME can be used interchangeably. One half of the puppies will carry one copy of the susceptibility markers (N/S), but will also be at low risk for developing NME. Symptoms of NME include seizures, depression, ataxia, abnormal gait, and blindness. J Vet Intern Med 2008: 22: 961–968. PDE is a fatal inflammatory brain disease. 8051 Arco Corporate Dr. Suite 300 Raleigh, NC 27617 (888)-682-9696,