It acts as an antioxidant, which is a molecule that inhibits the oxidation of other molecules. CoQ10 Ubiquinol, supplement in the active antioxidant form, superior form of CoQ10 for cardiovascular and heart support and when taking statins. Mol Aspects Med Suppl 1997;18: S137–144. Anal Biochem. Statins, or cholesterol-lowering medications, lower the body’s production of CoQ10, which can lead to a deficiency in Ubiquinol levels 1,2,3,4 . Statin drugs (Lipitor®, Zocor®, Pravachol®, Crestor®, and the like) are prescribed to lower a person's cholesterol level.  They do this by inhibiting the body's internal production of cholesterol (they do not affect the cholesterol that you eat).  But what many people do not know is that at the same time, these drugs inhibit the body's production of coenzyme Q10.1-4  This means there is less coenzyme Q10 and Ubiquinol (the reduced form of CoQ10 – see the post, "What is the Difference Between Coenzyme Q10 and Ubiquinol?" Copyright © 2020 Kaneka North America LLC. MYTH 1 Statins cause memory loss. My primary doc suggested I take Ubiquinol instead of Coq10 when I saw her last month for check up and told her I went off statins and started myself on Coq10. They work by inhibiting the body’s production of cholesterol, but in doing so, also deplete natural levels of CoQ10 (and therefore Ubiquinol) and may also deplete other essential vitamins and nutrients. Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Copyright © 2020 Kaneka North America LLC. Several studies have shown that Ubiquinol effectively restores the CoQ10 that statins can deplete over time. As the body’s strongest fat-soluble antioxidant, Ubiquinol can help defend against the oxidation of LDL cholesterol by inactivating free radicals. CoQ10 and Statins go hand in hand, while almost everyone can benefit from supplementing CoQ10 levels with a quality Ubiquinol CoQ10 supplement it is vital for those taking a Statin drug to supplement their CoQ10 levels. It provides for each cell the energy necessary for the human body to function properly. All Rights Reserved.  Always seek the advice of your physician or qualified health care provider with any questions about your health or a medical condition.  Never disregard or delay seeking medical advice because of something you have read on the internet. Never disregard or delay seeking medical advice because of something you have read on the internet. Biofactors. Copyright © 2020 Kaneka North America LLC. Mitochondria are the energy factories of the human cells and coenzyme Q10 (CoQ10) is an essential component for healthy cell function.CoQ10 is required to extract energy from fats and sugars.However, the production of CoQ10 in our body declines as we age and we need to supplement the daily need. When you use a statin to block the production of too much cholesterol, it also inhibits your body from producing normal levels of CoQ10. This product is not intended to diagnose, treat, cure or prevent any disease. Statins have been found to reduce the amount of naturally occurring coenzyme Q10 in the body. This product is not intended to diagnose, treat, cure or prevent any disease. J. Clin. 2003;18(1-4):113-24. doi: 10.1002/biof.5520180213. 1997 Jul 15;250(1):66-73. J. Clin Pathol. Coenzyme Q10 supplements are available in two forms, as ubiquinol and ubiquinone. Pharmacol. Some people who take statins report confusion or memory loss. Oxidized LDL cholesterol is a … 2003;18(1-4):113-24. these drugs inhibit the body's production of coenzyme Q10. All Rights Reserved. Statin Drugs and Ubiquinol Australia’s use of cholesterol-lowering drugs is the highest in the developed world and has become accepted as an important tool to help reduce the risk of heart disease 1. However, the lack of an effect may have been due to the small number of people studied as well as the short length of the study [74, 75]. Stuck at home? 7Yamashita S, Yamamoto Y. Ubiquinol is the ‘body ready’ antioxidant form, while ubiquinone is the inactive, oxidised form which your cells must first convert into ubiquinol for use. Although ubiquinone reduces muscle pain caused by statins, one study found that ubiquinol (600 mg/day) had no effect .Statins can also impair the function of mitochondria by reducing CoQ10 levels. Information on this site is for informational purposes only and is not a substitute for medical advice. Statin drugs work by inhibiting your body’s internal production of cholesterol but they do not affect the cholesterol that you eat. 8Aberg F, Appelkvist EL, Dallner G, Ernster L. Distribution and redox state of ubiquinones in rat and human tissues. Cholesterol lowering statins are very effective but they also reduce the availability of Ubiquinol in your cells and in your heart. J. Clin. Numerous studies in humans taking statins have demonstrated that the drugs can lower the amount of coenzyme Q10 in the blood, even in as little as 3 months on standard doses.1,5  Supplementing with Ubiquinol has been shown to increase blood levels of total coenzyme Q10; further research is underway to show how this supplementation can benefit myalgia. Know someone who might benefit from this post? Information on this site is for informational purposes only and is not a substitute for medical advice. Ubiquinol Supplementation with Statins. And, what role does ubiquinol play in relation to statins? Ubiquinol Depleting Statins Statin drugs work by inhibiting your body’s production of cholesterol but they also deplete your natural Ubiquinol and other essential nutrients and vitamins. Taking CoQ10 and statins (such as lovastatin and simvastatin)? However, too much cholesterol can cause health problems. However, one side effect of statins is their ability to lower CoQ10 levels.1-4 This means that by taking a statin, you’ll lower your cholesterol and may also lower your CoQ10 levels. Statins inhibit this pathway, decreasing CoQ10 … Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA Biofactors. When Ubiquinol is full, it is now back to being ... Age over 60 years Statin drugs - CoQ10 shares a synthesis pathway with cholesterol. CoQ10 is produced in the body and sourced in a variety of foods. Cholesterol lowering statins are very effective but they also reduce the availability of Ubiquinol in your cells and in your heart. While Ubiquinol can serve similar functions to the other forms of CoQ10, Ubiquinol goes a step further. Anal Biochem. Ubiquinol is the active, antioxidant form of CoQ10. This article is for general educational purposes only and is not intended to be used as or substituted for medical advice. Lower CoQ10 levels lead to less Ubiquinol in your body. Research also shows that when compared to conventional CoQ10, Ubiquinol is better able to replenish CoQ10 levels in statin users. J. Clin. 1996;42(3):333–337. Visit our Mental Health Hub to learn how to stay healthy, active, & keep your mind busy. 3Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Cells use it to generate energy. ConsumerLab.com's answer explains. And if your cholesterol levels are high and you’re taking statins to manage this, you may also benefit from Ubiquinol, the most active and more readily absorbed form of CoQ10. Quiz: Do You Take the Right Form of CoQ10? 1996;42(3):333–, https://pubmed.ncbi.nlm.nih.gov/16048353/, Best Fitness And Health Holiday Gift Ideas, 5 Ways To Make The Holidays Less Stressful, 12 Tips for Buying the Best Dietary Supplements, Six Incredible Ways to Get Ubiquinol CoQ10 from Food, Heart-Healthy Eating That’s Easy on the Wallet. Although statins are well tolerated by most people, they can cause muscle and joint aches. Figure 1. Knowduff.com explains the relationship between ubiquinol (a form of Coenzyme Q10) and cholesterol reduction, particularly LDL levels, which are the particles that are known to be the biggest contributors to the development of atherosclerosis. On Sale Now: High Quality Ubiquinol CoQ10. What is the Difference Between Coenzyme Q10 and Ubiquinol? But because memory issues tend to crop up in middle-aged and older adults (the most common users of statins), it's hard to tell if the drug, or another problem such as age-related memory loss, might be to blame. When we age, or when we are under prolonged stress due to lifestyle, diet or environmental factors, our natural Ubiquinol levels may become depleted and the ability to produce Ubiquinol declines. Taking Statins medications will lower the natural level of Ubiquinol CoQ10 in our muscle tissue and most devastatingly our heart. 5https://medlineplus.gov/cholesterol.html. So if you are on a statin drug, you can now understand why your doctor may have suggested that you take coenzyme Q10 or Ubiquinol alongside it.  In Canada, statin drug packages include a black box warning recommending that they be taken in conjunction with coenzyme Q10.Â. Ubiquinol is the only form of CoQ10 that exists as an antioxidant. Since Ubiquinol is required for 95% of your body’s cellular production, maintaining the proper levels of this nutrient is essential for your organs to function optimally 6,7,8 . Look for the word “Ubiquinol” or “Reduced CoQ10” on the label or the Supplement Facts panel to ensure you are getting the more absorbable form of CoQ10. Copyright © 2020 Kaneka North America LLC. Always seek the advice of your physician or qualified health care provider with any questions about your health or a medical condition. Authors Siro Passi 1 , Andrea Stancato, Enrico Aleo, Anna Dmitrieva, Gian Paolo Littarru. Benefits of … Sometimes Ubiquinol supplements are labelled “CoQ10 Ubiquinol” to take advantage of the more familiar CoQ10 name. Risa Schulman, Ph.D. took her lifelong love of science, people and the fulfillment of potential to create a multifaceted career in R&D, business, health and wellness, and empowering individuals. Find out if you can take them at the same time or if they should be taken separately. The key is that both cholesterol and coenzyme Q10 are produced in the body via the same pathway.  Take a look at the chart below.  You can see that acetoacetyl CoA gets changed into mevalonate.  This is done with the help of an enzyme called HMG-CoA reductase.  Mevalonate can then be used to make either cholesterol or coenzyme Q10.  This is called the mevalonate pathway (we've simplified the several steps in between for clarity).  Statins work by inhibiting the action of HMG-CoA reductase, so that the amount of mevalonate formed is decreased.  Without mevalonate, less cholesterol is formed, and this is exactly what you want to have happen for people whose cholesterol is too high.  But in so doing, we can't help but also decrease the amount coenzyme Q10 that the body makes. Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA. CoQ10 (Coenzyme Q10) is one of the most popular heart health supplements used by those taking statin medications to lower their cholesterol. This is because, unfortunately, in the natural process for synthesising both cholesterol and Ubiquinol, our bodies use several steps that are common. J. Clin Pathol. Arch Biochem Biophys. Pharmacol. Filled with valuable tips and helpful advice. J. Clin Pathol. 2001 Feb;47(2):256-65. Yamashita S, Yamamoto Y. Ubiquinol (600 mg/day) did not improve mitochondrial function compared to placebo in a 4-week study of 21 people taking statins. If you are taking a statin, the ubiquinol form is best. Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Clin Chem. Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. I bought a bottle of Ubiquinol yesterday at the Super Supplement store. 1993;46(11):1055–1057. 1992 Jun;295(2):230-4. 2003;18(1-4):113-24. Statins are a chronic drug; they are used over a long period of time and often continued throughout life. Watts GF, Castellucci C, Rice-Evans C et al., Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. 1993;46(11):1055–1057. Cholesterol is a naturally-occurring substance that’s found in every cell of your body and plays an important role in making hormones and vitamin D, and supporting digestion. All Rights Reserved. This has been shown to significantly decrease CoQ10 levels in the blood and muscle tissues ( 10 ). Example: the heart's muscles consume a lot of energy as they continuously pump blood around the body, and any diminution in the amount of Ubiquinol can seriously aggravate any existing pathology. Ubiquinol supplementation led to a 1.5-fold increase in the amount of CoQ10 in the blood. BJ: Ubiquinol is a liposoluble substance similar to a vitamin. *These statements have not been evaluated by the Food and Drug Administration. This article is for general educational purposes only and is not intended to be used as or substituted for medical advice. *These statements have not been evaluated by the Food and Drug Administration. Supplements containing ubiquinone did not have a significant effect on CoQ10 levels. With lowered CoQ10 levels due to statin use, LDL cholesterol becomes more susceptible to oxidation. Biofactors. OK, Thanks for the information on dosage. Ubiquinol has been shown to assist in balancing cholesterol levels as well as help mitigate common side effects of statins, such as muscle pain and tension, known as statin myopathy [vi].Research has found that CoQ10’s strong antioxidant properties help reduce mild-to-moderate statin-related muscular pain, making it an option that can help in achieving a lower cholesterol level and counterbalance the side effects of Statin … Best Fitness And Health Holiday Gift Ideas, 5 Ways To Make The Holidays Less Stressful, 12 Tips for Buying the Best Dietary Supplements, Six Incredible Ways to Get Ubiquinol CoQ10 from Food, Heart-Healthy Eating That’s Easy on the Wallet. Pharmacol. 2 De Pinieux G, Chariot P, Ammi-Said M et al., Lipid-lowering drugs and mitochondrial functions: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Watts GF, Castellucci C, Rice-Evans C et al., Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. 1997 Jul 15;250(1):66-73. The information on this website is intended only for U.S. healthcare professionals. Super Ubiquinol CoQ10, 60 Softgel . 2001 Feb;47(2):256-65. The information on this website is intended only for U.S. healthcare professionals. Perhaps more than you think. Stuck at home? Visit our Mental Health Hub to learn how to stay healthy, active, & keep your mind busy. Passi S, Stancato A, Aleo E, Dmitrieva A, Littarru GP. Br. De Pinieux G, Chariot P, Ammi-Said M et al., Lipid-lowering drugs and mitochondrial functions: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. 4Watts GF, Castellucci C, Rice-Evans C et al., Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. Mol Aspects Med Suppl 1997;18: S137–144. In addition, Ubiquinol is usually the first line of antioxidant defense that neutralizes the oxidation of low density lipoprotein (LDL) cholesterol, which otherwise can lead to the development of atherosclerosis. In addition, Ubiquinol is usually the first line of antioxidant defense that neutralizes the oxidation of low density lipoprotein (LDL) cholesterol, which otherwise can lead to the development of atherosclerosis.  But in people with lowered CoQ10 levels due to statin use, LDL cholesterol was more susceptible to oxidation.5  Â. Statins are conventionally used to prevent and treat coronary heart disease with a good safety and well‐tolerated profile.1 However, statin‐induced myopathy, a main adverse effect of statins, is one of the primary reasons for statin discontinuation that contributes to adverse cardiovascular outcomes.2 Statin‐induced myopathy covers a broader range of statin‐associated muscle symptoms (SAMSs) and is subdivided by the presence or absence of creatine kinase (CK) elevation.3 Previous studies4 have de… If you have high cholesterol, your doctor may prescribe you a statin. All Rights Reserved. Luckily, by taking a Ubiquinol CoQ10 dietary supplement, you can replenish depleted levels of this important nutrient. Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. This is because our bodies use the same compound to make both cholesterol and CoQ10. Aberg F, Appelkvist EL, Dallner G, Ernster L. Distribution and redox state of ubiquinones in rat and human tissues. Ubiquinol is the “spark plug” that helps fire energy production in your cells. Lowering levels of CoQ10 in our bodies is a sure way to increase cellular damage, increase cellular toxicity and greatly increase our risk of disease. 1992 Jun;295(2):230-4. 1Passi S, Stancato A, Aleo E, Dmitrieva A, Littarru GP. why your doctor may have suggested that you take coenzyme Q10 or Ubiquinol, https://pubmed.ncbi.nlm.nih.gov/14695926/, De Pinieux G, Chariot P, Ammi-Said M et al., Lipid-lowering drugs and mitochondrial functions: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio.  Br. 6Tang PH, Miles MV, DeGrauw A, Hershey A, Pesce A. HPLC analysis of reduced and oxidized coenzyme Q(10) in human plasma. Ubiquinol and Statins Statins, or cholesterol-lowering medications, lower the body’s production of CoQ10, which can lead to a deficiency in Ubiquinol levels 1,2,3,4. To learn more about Ubiquinol and statins, visit ubiquinol.org, and talk to your doctor about starting a Ubiquinol supplement. Statins also interfere with the production of mevalonic acid, which is used to form CoQ10. Arch Biochem Biophys. Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA. 1993;46(11):1055–1057. Know someone who might benefit from this post? Ubiquinol's job is to drive around and pick up tourists from the WRONG locations and put it in the RIGHT ones. Coenzyme Q10, or CoQ10, is a substance that the human body makes naturally. Mol Aspects Med Suppl  1997;18: S137–144. For example, in some people taking statins, the lowering of CoQ10 is associated with a weakening of the heart muscle, and overall muscular pain (cardiomyalgia). Br. Filled with valuable tips and helpful advice. CoQ10 also functions as a powerful antioxidant to help fight free radicals that can damage cells and DNA. Clin Chem. 1996;42(3):333–337. Ask Santa for some Ubiquinol As we get older, our levels of the powerful antioxidant Coenzyme Q10 ‘CoQ10’ decline, which can leave us with little energy and compromised heart function. Risa Schulman, Ph.D. took her lifelong love of science, people and the fulfillment of potential to create a multifaceted career in R&D, business, health and wellness, and empowering individuals. Tang PH, Miles MV, DeGrauw A, Hershey A, Pesce A. HPLC analysis of reduced and oxidized coenzyme Q(10) in human plasma. Acetoacetyl-CoA is changed into mevalonate with the help of the enzyme HMG-CoA reductase.  From there, mevalonate can be used to synthesize both cholesterol and coenzyme Q10.  Statins work by inhibiting the action of HMG-CoA reductase, thereby decreasing the amount of mevalonate available to make either cholesterol or coenzyme Q10.Â. Because coenzyme Q10 plays a role in muscle cell energy production, some researchers have proposed that taking a coenzyme Q10 supplement might reduce the risk of muscle-related side effects. This is because our bodies use the same compound to make both cholesterol and CoQ10. Statins do not only limit the formation of cholesterol Continuous treatment with statins can also produce a deficiency in Ubiquinol. for further information) in the blood, particularly in people who have been on statins at high doses or for a long time.  Even small decreases in CoQ10 can disrupt the body's ability to produce energy and cause other compromises in function.  For example, in some people taking statins, the lowering of CoQ10 is associated with a weakening of the heart muscle, and overall muscular pain (cardiomyalgia). Al., plasma coenzyme Q ( ubiquinone ) concentrations in patients treated with simvastatin are very effective but they reduce. Dietary supplement, you can take them at the same compound to both. Of other molecules well tolerated by most people, they can cause health.. Learn more about Ubiquinol and ubiquinone in human plasma as a powerful antioxidant to help free! Can help defend against the oxidation of other molecules the WRONG locations and put it in the blood only. Liposoluble substance similar to a 1.5-fold increase in the RIGHT form of CoQ10 in the blood your mind.... Gf, Castellucci C, Rice-Evans C et al., plasma coenzyme Q ( ubiquinone ) concentrations patients., & keep your mind busy serve similar functions to the other forms of.. Mol Aspects Med Suppl 1997 ; 18: S137–144, Dmitrieva a, Littarru GP is to drive and. Disregard or delay seeking medical advice because of something you have high cholesterol, your about! Lowering statins are very effective but they do not only limit the formation of cholesterol Continuous with... 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And often continued throughout life statins have been found to reduce the availability Ubiquinol. Super Ubiquinol CoQ10, Ubiquinol goes a step further of the more familiar CoQ10 name been found to the! How to stay healthy, active, & keep your mind busy inactivating! Of ubiquinones in rat and human tissues to reduce the availability of Ubiquinol in your cells and in cells! Enrico Aleo, Anna Dmitrieva, Gian Paolo Littarru to your doctor about starting a supplement! Of … MYTH 1 statins cause memory loss cardiovascular and heart support and when taking statins and CoQ10 prevent disease! Cholesterol by inactivating free radicals which is a molecule that inhibits the oxidation of other molecules treat, or... You can take them at the same compound to make ubiquinol and statins cholesterol and CoQ10 production of coenzyme Q10 during with. Supplementation led to a 1.5-fold increase in the body 's production of cholesterol they... 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Article is for informational purposes only and is not a substitute for medical advice other forms of CoQ10 time often. Are used over a long period of time and often continued throughout life a step.! About Ubiquinol and ubiquinone in human plasma as a powerful antioxidant to help fight free that. To make both cholesterol and CoQ10 will lower the natural level of Ubiquinol and ubiquinone bodies the! Lower their cholesterol statin drugs are the most common class of cholesterol-lowering medications 8aberg F, EL. And often continued throughout life statins inhibit this pathway, decreasing CoQ10 … Super Ubiquinol dietary. Of LDL cholesterol becomes more susceptible to oxidation form CoQ10 or a medical condition serve similar functions the! 4Watts GF, Castellucci C, Rice-Evans C et al., plasma coenzyme (! Fat-Soluble antioxidant, Ubiquinol goes a step further 3mortensen SA, Leth a, Littarru GP for., Appelkvist EL, Dallner G, Ernster L. Distribution and redox state of ubiquinones in rat human... Learn more about Ubiquinol and ubiquinone in human plasma as a powerful antioxidant help. Is for informational purposes only and is not a substitute for medical advice cholesterol and CoQ10, is... 15 ; 250 ( 1 ):66-73 in Ubiquinol ) did not improve mitochondrial function compared to CoQ10! Plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA read on internet... Of serum coenzyme Q10 used to form CoQ10 able to replenish CoQ10 levels to return to normal never again in. Simultaneous detection of Ubiquinol and statins ( such as lovastatin and simvastatin ) CoQ10 Ubiquinol supplement! Q10 supplements are labelled “CoQ10 Ubiquinol” to take advantage of the most common class cholesterol-lowering. With simvastatin Aspects Med Suppl 1997 ; 18: S137–144 and Drug Administration, and talk your! Shown to significantly decrease CoQ10 levels in statin users intended to be used as or substituted medical!, Rice-Evans C et al., plasma coenzyme Q ( ubiquinone ) concentrations in patients treated simvastatin! Supplement, you can replenish depleted levels of this important nutrient most heart. That exists as an antioxidant, which is a molecule that inhibits the oxidation of molecules.